Recently, I encountered an issue where by every time I plugged in or unplugged a USB device when VirtualBox was running (no need for a VM to be up just the main VirtualBox app), then my system would blue screen.
Having looked into the issue at length, I came across a post online about the potential for other system/low level USB system hooking drivers, to casue issues with the VirtualBox USB monitor driver. This set me reviewing recent system changes and looking through that list, I noted I recently installed the full Wireshark package (all features) and that has a lowlevel USB driver in it. So to check if this was the source of the conflict I removed that (including the USBpcap component) and the issue cleared up.
The only conclusion I can come to is that there is some kind of conflict between the two drivers, so for now the plan is to not install USBpcap on any host that has VirtualBox on it.